Take I-678N (Van Wyck Expressway) from JFK International Airport to I-495W. Continue to the Queens-Midtown Tunnel and take the Downtown exit. Keep left and follow the signs for Crosstown/37th Street/3rd Avenue. Stay on E 37th Street until you reach 6th Avenue. Make a right on 6th Avenue and continue to The Royalton Hotel at 44 W 44th Street.
Take the 1, 2, or 3 train from the 34th St. - Penn Station stop, direction Wakefield - 241 St., until you reach Times Square - 42 St. Exit the subway on W 42 St. and walk east, towards Bryant Park. Make a left at 6th Ave, and then a right on W 44th St. The Royalton Hotel will be on your right.